Self‐Regulating Colloidal Co‐Assemblies that Accelerate their Own Destruction via Chemo‐Structural Feedback

Biological self-assemblies self- and cross-regulate each other via chemical reaction networks (CRNs) feedback. Although artificial transient have been realized activation/deactivation CRNs, the structures themselves do mostly not engage in CRN. We introduce a rational design approach for chemo-structural feedback, present colloidal co-assembly system, where formed co-assemblies accelerate their destruction autonomously. achieve this by immobilizing enzymes of deactivating acid-producing enzymatic cascade on pH-switchable microgels that can form at high pH. Since enzyme partners are immobilized individual microgels, co-assembled state brings them close enough enhanced acid generation. The amplified deactivator production (acid) leads to an almost two-fold reduction lifetime transiently pH-state. Our study thus introduces versatile mechanisms